Brain dynamics in health and in disease

Key collaborator: Dr Simon Farmer (UCL Queen Square)

Graduate students: Miss Maryam Gholampour (PhD 2023-), Mr Enrico Caprioglio (PhD 2022-), Miss Eleanna Kritikaki (PhD 2019-), Dr Tim West (PhD, 2015-2018, UCL CoMPLEX, now postdoctoral neuroscientist at University of Oxford), Dr Maria Botcharova (PhD, 2010-2013, UCL CoMPLEX), Dr Tim Taylor (PhD, 2012-2015), Dr Caroline Hartley (PhD, 2009-2012; now Associate Professor & Wellcome Trust/Royal Society Sir Henry Dale Fellow @ University of Oxford)

Topics of interest here include:

Pathological synchronisation in Parkinson's Disease

West, T. O., Berthouze, L., Farmer, S. F., Cagnan, H., & Litvak, V. (2019). Mechanistic Inference of Brain Network Dynamics with Approximate Bayesian Computation. BioRxiv, 785568. https://doi.org/10.1101/785568

West, T. O., Berthouze, L., Halliday, D. M., Litvak, V., Sharott, A., Magill, P. J., & Farmer, S. F. (2018). Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat. Journal of Neurophysiology, 119(5), 1608–1628. https://doi.org/10.1152/jn.00629.2017

West, T., Farmer, S., Berthouze, L., Jha, A., Beudel, M., Foltynie, T., Limousin, P., Zrinzo, L., Brown, P., & Litvak, V. (2016). The Parkinsonian Subthalamic Network: Measures of Power, Linear, and Non-linear Synchronization and their Relationship to L-DOPA Treatment and OFF State Motor Severity. Frontiers in Human Neuroscience, 10, 517. https://doi.org/10.3389/fnhum.2016.00517

Brain criticality, long-range temporal correlations in amplitude and phase synchrony

Hartley, C., Farmer, S., & Berthouze, L. (2020). Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex. PLOS ONE, 15(1), e0226772. https://doi.org/10.1371/journal.pone.0226772

Botcharova, M., Berthouze, L., Brookes, M. J., Barnes, G. R., & Farmer, S. F. (2015). Resting state MEG oscillations show long-range temporal correlations of phase synchrony that break down during finger movement. Frontiers in Physiology, 6, 183. https://doi.org/10.3389/fphys.2015.00183

Botcharova, M., Farmer, S. F., & Berthouze, L. (2014). Markers of criticality in phase synchronization. Frontiers in Systems Neuroscience, 8, 176. https://doi.org/10.3389/fnsys.2014.00176

Hartley, C., Taylor, T. J., Kiss, I. Z., Farmer, S. F., & Berthouze, L. (2014). Identification of Criticality in Neuronal Avalanches: II. A Theoretical and Empirical Investigation of the Driven Case. Journal of Mathematical Neuroscience, 4, 9. https://doi.org/10.1186/2190-8567-4-9

Taylor, T. J., Hartley, C., Simon, P. L., Kiss, I. Z., & Berthouze, L. (2013). Identification of Criticality in Neuronal Avalanches: I. A Theoretical Investigation of the Non-driven Case. Journal of Mathematical Neuroscience, 3(1), 5. https://doi.org/10.1186/2190-8567-3-5

Botcharova, M., Farmer, S. F., & Berthouze, L. (2012). Power-law distribution of phase-locking intervals does not imply critical interaction. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 86(5 Pt 1), 051920. https://doi.org/10.1103/PhysRevE.86.051920

Hartley, C., Berthouze, L., Mathieson, S. R., Boylan, G. B., Rennie, J. M., Marlow, N., & Farmer, S. F. (2012). Long-range temporal correlations in the EEG bursts of human preterm babies. PloS One, 7(2), e31543. https://doi.org/10.1371/journal.pone.0031543

Berthouze, L., & Farmer, S. F. (2012). Adaptive time-varying detrended fluctuation analysis. Journal of Neuroscience Methods, 209(1), 178–188. https://doi.org/10.1016/j.jneumeth.2012.05.030

Berthouze, L., James, L. M., & Farmer, S. F. (2010). Human EEG shows long-range temporal correlations of oscillation amplitude in Theta, Alpha and Beta bands across a wide age range. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 121(8), 1187–1197. https://doi.org/10.1016/j.clinph.2010.02.163

Coherence

Ward, N. J., Farmer, S. F., Berthouze, L., & Halliday, D. M. (2013). Rectification of EMG in low force contractions improves detection of motor unit coherence in the beta-frequency band. Journal of Neurophysiology, 110(8), 1744–1750. https://doi.org/10.1152/jn.00296.2013